Ampicillin and Sulbactam Essay

Pregnancy Category: B| Bactericidal action. Active against: Streptococci,Penumococci,Enterococci,Haemophilus influenzae. Binds to bacteria cell wall, resulting in cell death, spectrum is broader than that of penicillin. Addition of sulbactam increases resistance to beta-lactamase, enzymes produced by bacteria that may inactivate ampicillin. * Treatment of infections caused by susceptible strains of Shigella, Salmonella, E. Coli, Haemophilus influenza, S. typhosa, N. Gonorrhea, enterococci, gram-positive organisms * Meningitis caused by Neisseria meningitides| * Contraindicated with allergies to penicillins, cephalosporins, or other allergens. * Use cautiously with renal disorders.

* CNS: Lethargy,hallucinations, seizures * CV: Heart failure * GI: Glossitis, stomatitis, gastritis, soremouth, nausea, vomiting, diarrhea, abdominal pain, bloody diarrhea, enterocolitis, pseudo membranous colitis, nonspecific hepatitis * GU: Nephritis * Hematology: Anemia, thrombocytopenia, leukopenia, neutropenia, prolonged bleeding time * Hypersensitivity: Rash, fever, wheezing, anaphylaxis * Local: Pain, phlebitis, thrombosis * Other:Superinfection| * Assess patient for infection (vital signs, wound appearance, sputum, urine, stool, and WBCs) at beginning and through out therapy. Obtain a history before initiating therapy to determine previous use of and reactions to penicillins or cephalosporins. Persons with a negative history of penicillin sensitivity may still have an allergic response. * Obtain specimens for culture and sensitivity before therapy. First dose may be given before receiving results. * Observe patients for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing).

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Discontinue the drug and notify the physician immediately if these occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in the event of an anaphylactic reaction. * Caution patient to notify physician if fever and diarrhea occur, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting healthcare professional. * May occur up to several weeks after discontinuation.